Anthony (Tony) Melillo, M.S.

Education

M.S., Computer Science, University of New Haven
B.S., Biological Sciences, University of Connecticut

About Tony

I teach courses in bioinformatics, biostatistics, database design, genomics and computer programming. My teaching philosophy is heavily influenced by my experiences both as a student and as someone with extensive experience in information technology, bioinformatics and data science. The overall goal of my classes is for students to learn how to solve real-world problems, and overcome the typical fears associated with informatics. To reach this goal my students spend most of their time on active learning, using online tools, performing data analysis and creating custom solutions.

Research Interests

Analysis of differential expression using RNA-seq.
Utilizing DNA and RNA-seq to detect infectious organisms in host tissues.

Recent Publications

Khatri VA, Paul S, Patel NJ, Thippani S, Sawant JY, Durkee KL, Murphy CL, Aleman GO, Valentino JA, Jathan J, Melillo A, Sapi E. Global Transcriptomic Analysis of Breast Cancer and Normal Mammary Epithelial Cells Infected with Borrelia burgdorferi. Eur J Microbiol Immunol (Bp). 2023 Oct 19. doi: 10.1556/1886.2023.00031. PMID: 37856211.

Konstorum A, Mohanty S, Zhao Y, Melillo A, Vander Wyk B, Nelson A, Tsang S, Blevins TP, Belshe RB, Chawla DG, Rondina MT, Gill TM, Montgomery RR, Allore HG, Kleinstein SH, Shaw AC. Platelet Response to Influenza Vaccination Reflects Effects of Aging. Aging Cell. 2023 Feb;22(2):e13749. doi: 10.1111/acel.13749. Epub 2023 Jan 19. PMID: 36656789; PMCID: PMC9924941.

Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C Jr, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K; Yale IMPACT Research Team; Niklason LE, Ko AI, Montgomery RR, Farhadian SF, Iwasaki A, Shaw AC, van Dijk D, Zhao H, Kleinstein SH, Hafler DA, Kaminski N, Dela Cruz CS. Single-cell Multi-omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19. Nat Commun. 2022 Jan 21;13(1):440. doi: 10.1038/s41467-021-27716-4. PMID: 35064122; PMCID: PMC8782894.

Sapi E, Kasliwala RS, Ismail H, Torres JP, Oldakowski M, Markland S, Gaur G, Melillo A, Eisendle K, Liegner KB, Libien J, Goldman JE. The Long-Term Persistence of Borrelia burgdorferi Antigens and DNA in the Tissues of a Patient with Lyme Disease. Antibiotics (Basel). 2019 Oct 11;8(4):183. doi: 10.3390/antibiotics8040183. PMID: 31614557; PMCID: PMC6963883.

Middelveen MJ, Filush KR, Bandoski C, Kasliwala RS, Melillo A, Stricker RB, Sapi E. Mixed Borrelia burgdorferi and Helicobacter pylori Biofilms in Morgellons Disease Dermatological Specimens. Healthcare (Basel). 2019 May 17;7(2):70. doi: 10.3390/healthcare7020070. PMID: 31108976; PMCID: PMC6627092.